Article
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein science : a publication of the Protein Society - 1 Apr 2006
Dunn Steven M, Rizkallah Pierre J, Baston Emma, Mahon Tara, Cameron Brian, Moysey Ruth, Gao Feng, Sami Malkit, Boulter Jonathan, Li Yi, Jakobsen Bent K
Abstract excerpt
The mammalian alpha/beta T cell receptor (TCR) repertoire plays a pivotal role in adaptive immunity by recognizing short, processed, peptide antigens bound in the context of a highly diverse family of cell-surface major histocompatibility complexes (pMHCs). Despite the extensive TCR-MHC interaction surface, peptide-independent cross-reactivity of native TCRs is generally avoided through cell-mediated selection of...
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