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Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display

13 Jul 2011

Abstract excerpt

Reliable and robust systems for engineering functional major histocompatibility complex class II (MHCII) proteins have proved elusive. Availability of such systems would enable the engineering of peptide-MHCII (pMHCII) complexes for therapeutic and diagnostic applications. In this paper, we have developed a system based on insect cell surface display that allows functional expression of heterodimeric DR2...

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PMID: 21752831
DOI: 10.1093/protein/gzr035

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