Article
Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women.
Drug and alcohol dependence - 15 Sept 2006
Lorenzo Alfons, Auguet Teresa, Vidal Francesc, Broch Montserrat, Olona Montserrat, Gutiérrez Cristina, López-Dupla Miguel, Sirvent Joan-Josep, Quer Joan-Carles, Santos Mauro, Richart Cristóbal
Abstract excerpt
BACKGROUND: The relationship of polymorphisms of the genes that encode for alcohol-metabolizing enzymes and individual vulnerability to alcoholism and alcoholic liver disease (ALD) in women is unclear. We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women. METHODS: We performed a cross-sectional case-control study. The study group was made of 220...
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