Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women.

doi:10.1016/j.drugalcdep.2006.03.002

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Article

Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women.

Drug and alcohol dependence - 15 Sept 2006

Lorenzo Alfons, Auguet Teresa, Vidal Francesc, Broch Montserrat, Olona Montserrat, Gutiérrez Cristina, López-Dupla Miguel, Sirvent Joan-Josep, Quer Joan-Carles, Santos Mauro, Richart Cristóbal

Abstract excerpt

BACKGROUND: The relationship of polymorphisms of the genes that encode for alcohol-metabolizing enzymes and individual vulnerability to alcoholism and alcoholic liver disease (ALD) in women is unclear. We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women. METHODS: We performed a cross-sectional case-control study. The study group was made of 220...

Topics

Alcohol Dehydrogenase
Alcoholism
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Alleles
Case-Control Studies
Cross-Sectional Studies
Cytochrome P-450 CYP2E1
Ethanol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Frequency

Genotype

Humans

Liver Cirrhosis, Alcoholic

Middle Aged

Polymorphism, Genetic

Risk Factors

Spain

Source

Open in PubMed

Identifiers

PMID: 16600530
DOI: 10.1016/j.drugalcdep.2006.03.002

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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