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Article

Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer.

Alcoholism, clinical and experimental research - 1 Mar 2007

Visvanathan Kala, Crum Rosa M, Strickland Paul T, You Xiaojun, Ruczinski Ingo, Berndt Sonja I, Alberg Anthony J, Hoffman Sandra C, Comstock George W, Bell Douglas A, Helzlsouer Kathy J

Abstract excerpt

BACKGROUND: In vitro, human isoenzymes encoded by genes homozygous for the ADH1C*1 or ADH1B*2 alleles metabolize ethanol to acetaldehyde at a faster rate than those homozygous for the ADH1C*2 or ADH1B*1 allele. Because alcohol is a known risk factor for breast cancer, we evaluated the joint association of genetic variants in ADH and alcohol consumption in relation to breast cancer. METHODS: A nested case-control...

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Identifiers

PMID: 17295732
DOI: 10.1111/j.1530-0277.2006.00334.x
PMCID: PMC2787101

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Source receipt: pubmed, retrieved 7 Sept 2026.

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