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Article

Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population.

Clinical chemistry and laboratory medicine - 1 Jan 2008

Tamm Riin, Oselin Kersti, Kallassalu Kristi, Magi Reedik, Anier Kaili, Remm Maido, Metspalu Andres

Abstract excerpt

BACKGROUND: Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs. To date, at least 25 single nucleotide polymorphisms have been reported in the TPMT gene, 23 of these are associated with reduced enzyme activity. METHODS: The aim of the present study was to sequence the whole coding region of TPMT (exons 3-10) to identify known and novel TPMT sequence variants...

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Source

Identifiers

PMID: 18605963
DOI: 10.1515/CCLM.2008.187

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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