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Article

Distribution of TPMT risk alleles for thiopurine [correction of thioupurine] toxicity in the Israeli population.

European journal of clinical pharmacology - 1 Mar 2009

Efrati Edna, Adler Lior, Krivoy Norberto, Sprecher Eli

Abstract excerpt

BACKGROUND AND OBJECTIVE: Individuals with intermediate or no thiopurine S-methyltransferase (TPMT) activity are at risk of hematotoxicity when treated with standard doses of thiopurines, thus, pretreatment identification of these individuals is of major importance. The purpose of this study was to determine the frequency and distribution of TPMT polymorphic variants, known to functionally impair TPMT activity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19048244
DOI: 10.1007/s00228-008-0590-7

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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