Article
Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2006
Honeyborne Isobella, Rathod Almas, Buchli Rico, Ramduth Dhanwanthie, Moodley Eshia, Rathnavalu Prinisha, Chetty Senica, Day Cheryl, Brander Christian, Hildebrand William, Walker Bruce D, Kiepiela Photini, Goulder Philip J R
Abstract excerpt
HIV-specific CTL play a central role in immune control of HIV. The basis for understanding the success or failure of this immune response requires identification of the specific epitopes targeted by CTL. However, in populations most severely affected by the global epidemic, this fundamental knowledge is hindered by the lack of characterization of many of the HLA class I alleles highly prevalent in such...
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