Article
Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation.
Molecular cell - 11 Jul 2008
Saguez Cyril, Schmid Manfred, Olesen Jens Raabjerg, Ghazy Mohamed Abd El-Hady, Qu Xiangping, Poulsen Mathias Bach, Nasser Tommy, Moore Claire, Jensen Torben Heick
Abstract excerpt
The yeast THO complex and the associated RNA helicase Sub2p are important mRNP maturation factors. Transcripts produced in THO/sub2 mutants are subject to degradation by a surveillance mechanism that involves the nuclear RNA exosome. Here we show that inefficient polyadenylation forms the basis of this accelerated mRNA decay. A genetic screen reveals extensive interactions between deletions of THO subunits and...
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