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Article

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.

The Journal of biological chemistry - 14 Mar 2003

Li Bing, Howe LeAnn, Anderson Scott, Yates John R, Workman Jerry L

Abstract excerpt

The histone methyltransferase Set2, which specifically methylates lysine 36 of histone H3, has been shown to repress transcription upon tethering to a heterologous promoter. However, the mechanism of targeting and the consequence of Set2-dependent methylation have yet to be demonstrated. We sought to identify the protein components associated with Set2 to gain some insights into the in vivo function of this...

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Identifiers

PMID: 12511561
DOI: 10.1074/jbc.M212134200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.PMID 12511561Read ↗

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.Semantic proximity Read ↗

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.Semantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6.Semantic proximity Read ↗

Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin.Semantic proximity Read ↗

SETD2: an epigenetic modifier with tumor suppressor functionality.Semantic proximity Read ↗

Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.Semantic proximity Read ↗

SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.Semantic proximity Read ↗

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