Article
Polymorphisms within the tumor necrosis factor-alpha promoter region in patients with HLA-B27-associated uveitis: association with susceptibility and clinical manifestations.
Ophthalmology - 1 Apr 2006
El-Shabrawi Yosuf, Wegscheider Beate J, Weger Martin, Renner Wilfried, Posch Ursula, Ulrich Silvia, Ardjomand Navid, Hermann Josef
Abstract excerpt
PURPOSE: The existence of genetic variations in a number of cytokines has been considered to influence susceptibility or relate to disease severity in various autoimmune diseases. Among these, single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF-alpha) promoter at nucleotides -308 and -238 are considered to be protective against inflammation in HLA-B27-positive individuals, whereas the...
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