Article
HLA-B27 subtypes and tumor necrosis factor alpha promoter region polymorphism in Iranian patients with ankylosing spondylitis.
European cytokine network - 1 Mar 2009
Nicknam Mohammad Hossein, Mahmoudi Mahdi, Amirzargar Ali Akbar, Jamshidi Ahmad Reza, Rezaei Nima, Nikbin Behrouz
Abstract excerpt
BACKGROUND: HLA-B27 is an MHC class I molecule that is strongly associated with ankylosing spondylitis (AS). TNF-alpha, as an important cytokine in inflammatory joint disease, might have a role in the process of AS. This study was performed to determine HLA-B27 subtypes among Iranian patients with AS, and to investigate TNF-alpha gene polymorphisms in the patient groups. METHODS: Ninety seven AS patients (74...
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