Article
Polymorphism within the tumor necrosis factor alpha (TNF) promoter region in patients with ankylosing spondylitis.
Human immunology - 1 Feb 1999
Kaijzel E L, Brinkman B M, van Krugten M V, Smith L, Huizinga T W, Verjans G M, Breedveld F C, Verweij C L
Abstract excerpt
In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the location of the TNF gene in the vicinity of the HLA-B locus, and the prominent role in inflammation of its product, we investigated the association between AS and two G to A transition polymorphisms located at position -238 and -376 in the promoter region of the TNF gene. The...
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