Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population.

doi:10.1155/2018/1395823

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Article

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population.

Mediators of inflammation - 1 Jan 2018

Rocha Loures Marco A, Macedo Luciana C, Reis Denise M, Oliveira Camila F, Meneguetti Jean L, Martines Gabriela F, Neves Janisleya S F, de Souza Eliana, Sell Ana M, Visentainer Jeane E L

Abstract excerpt

BACKGROUND AND OBJECTIVES: Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms of TNF and IL17 genes are associated with SpA, ankylosing spondylitis (AS), and psoriatic arthritis (PsA)...

Topics

Adult
Arthritis, Psoriatic
Brazil
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
HLA-B27 Antigen
Humans
Interleukin-17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Spondylarthritis

Spondylitis, Ankylosing

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 29849482
DOI: 10.1155/2018/1395823
PMCID: PMC5933012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29849482-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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