Article
Relation of HLA-B27, tumor necrosis factor-α promoter gene polymorphisms, and T cell cytokine production in ankylosing spondylitis -- a comprehensive genotype-phenotype analysis from an observational cohort.
The Journal of rheumatology - 1 Nov 2011
Poddubnyy Denis A, Märker-Hermann Elisabeth, Kaluza-Schilling Wiebke, Zeidler Henning, Braun Jurgen, Listing Joachim, Sieper Joachim, Rudwaleit Martin
Abstract excerpt
OBJECTIVE: In a pilot study, a distinct T cell cytokine pattern associated with HLA-B27 status and a tumor necrosis factor-α (TNF-α) promoter gene polymorphism was found at -308 (TNF-308). The objective of our study was to assess these associations in a different cohort of patients with ankylosing spondylitis (AS) and to evaluate any effect on clinical measurements. METHODS: Peripheral T cell cytokine production...
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