Article
Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients.
Nitric oxide : biology and chemistry - 1 Dec 2006
de Syllos Roger W C, Sandrim Valeria C, Lisboa Hugo R K, Tres Glaucia S, Tanus-Santos Jose E
Abstract excerpt
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated with the development of diabetic retinopathy (DR) in patients with type 1 diabetes mellitus (T1DM), but not with T2DM. However, no previous study has analyzed combinations of genetic markers (haplotypes), which can be more informative. We studied three eNOS genetic polymorphisms: a single nucleotide polymorphism in the...
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