Article
Endothelial nitric oxide synthase Glu298Asp, 4b/a, and T-786C polymorphisms in type 2 diabetic retinopathy.
Clinical endocrinology - 1 Apr 2008
Ezzidi Intissar, Mtiraoui Nabil, Mohamed Manel Ben Hadj, Mahjoub Touhami, Kacem Maha, Almawi Wassim Y
Abstract excerpt
OBJECTIVE: The possible association between the endothelial nitric oxide (eNOS) gene T-786C (promoter region), 27-bp repeat 4b/4a (intron 4), and Glu298Asp (exon 7) polymorphisms with diabetic retinopathy (DR) was investigated. DESIGN: A retrospective case-control study. PATIENTS: A total of 872 type 2 diabetes (T2DM) patients were studied, of whom 383 presented with preproliferative/proliferative retinopathy (DR...
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