Article
eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy.
Diabetic medicine : a journal of the British Diabetic Association - 1 Mar 2002
Taverna M J, Sola A, Guyot-Argenton C, Pacher N, Bruzzo F, Chevalier A, Slama G, Reach G, Selam J-L
Abstract excerpt
BACKGROUND: Genetic factors may be involved in the development, and particularly in the severity, of diabetic retinopathy (DR), in addition to chronic hyperglycaemia. Increased nitric oxide generation has been suggested to play a significant role in the pathogenesis of DR. AIMS AND METHODS: To examine whether the eNOS4 is involved in the risk of severe DR, 200 unrelated Caucasian Type 1 diabetic patients of long...
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