Article
Endothelial nitric oxide genotypes and haplotypes are not associated with end-stage renal disease.
DNA and cell biology - 1 Jan 2011
Marson Bernardo P, Dickel Samantha, Ishizawa Marília H, Metzger Ingrid F, Izidoro-Toledo Tatiane, da Costa Bartira Ercília Pinheiro, Poli-de-Figueiredo Carlos E, Tanus-Santos Jose E
Abstract excerpt
The identification of genetic markers associated with chronic kidney disease (CKD) may help to predict its development. Because reduced nitric oxide (NO) bioavailability and endothelial dysfunction are involved in CKD, genetic polymorphisms in the gene encoding the enzyme involved in NO synthesis (endothelial NO synthase [eNos]) may affect the susceptibility to CKD and the development of end-stage renal disease...
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