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Article

The effect of xenobiotic exposure on spontaneous autoimmunity in (SWR x SJL)F1 hybrid mice.

Journal of toxicology and environmental health. Part A - 1 Mar 2006

Hultman P, Taylor A, Yang J M, Pollard K M

Abstract excerpt

F1 hybrids of SWR (H-2(q)) and SJL (H-2(s)) mice spontaneously develop a lupuslike condition in an age-dependent manner, and these two H-2 haplotypes also confer susceptibility to induction of systemic autoimmunity by heavy metals such as mercury, silver, and gold with anti-fibrillarin antibodies (AFA) as marker. The aim of this study was to determine how the mixing of two susceptible genomes might influence...

Topics

Age Factors
Animals
Antibodies, Antinuclear
Antibody Formation
Autoimmunity
Female
Genetic Predisposition to Disease
Genome
Glomerulonephritis
Male
Mercury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred Strains

Silver

Source

Identifiers

PMID: 16574626
DOI: 10.1080/15287390500354904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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