Crystalline silica exposure of genetically diverse mice exacerbates subclinical autoimmunity into systemic autoimmune disease phenotypes including inflammatory arthritis in female mice.

Abstract excerpt

Inhalation of respirable crystalline silica (c-silica), an occupational hazard, has been associated with the development of systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, it is unclear if c-silica-mediated autoimmune disease requires pre-existing subclinical autoimmunity or to what extent the severity of existing subclinical autoimmunity influences the...

Topics

• Animals
• Female
• Silicon Dioxide
• Mice
• Autoimmunity
• Phenotype