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Article

Frizzled-related protein variants are risk factors for hip osteoarthritis.

Arthritis and rheumatism - 1 Apr 2006

Lane N E, Lian K, Nevitt M C, Zmuda J M, Lui L, Li J, Wang J, Fontecha M, Umblas N, Rosenbach M, de Leon P, Corr M

Abstract excerpt

OBJECTIVE: To examine the association of the Arg200Trp and Arg324Gly variants of FRZB with the risk and phenotype of radiographic osteoarthritis (OA) of the hip and serum levels of Frizzled-related protein (FRP) in a prospective cohort of elderly Caucasian women. METHODS: Radiographic hip OA status of patients was defined by the presence of severe joint space narrowing (JSN) (feature grade>or=3), a summary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16572458
DOI: 10.1002/art.21673

Genes

FRZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Frizzled-related protein variants are risk factors for hip osteoarthritis.PMID 16572458Read ↗

Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis.Semantic proximity Read ↗

Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites.Semantic proximity Read ↗

Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.Semantic proximity Read ↗

Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosisSemantic proximity Read ↗

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.Semantic proximity Read ↗

Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.Semantic proximity Read ↗

The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk.Semantic proximity Read ↗

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Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.Semantic proximity Read ↗

FRZB1 rs2242070 polymorphisms is associated with brick tea type skeletal fluorosis in Kazakhs, but not in Tibetans, China.Semantic proximity Read ↗

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