Article
Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.
Cancer causes & control : CCC - 1 May 2009
Berndt Sonja I, Huang Wen-Yi, Yeager Meredith, Weissfeld Joel L, Chanock Stephen J, Hayes Richard B
Abstract excerpt
OBJECTIVE: The Wnt/APC/beta-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly...
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