Article
Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites.
Arthritis and rheumatism - 1 Apr 2005
Min J L, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat J J, Seymour A B, Pols H A, van Duijn C M, Slagboom P E
Abstract excerpt
OBJECTIVE: To confirm the association of 2 variants of the Frizzled-related protein gene (FRZB) with osteoarthritis (OA) of the hip, and to investigate whether these variants also associate with other heritable generalized OA phenotypes. METHODS: An association analysis of 2 variants (R200W and R324G) of FRZB was performed in a random sample of 1,369 subjects (ages 55-70 years) from a population-based cohort (the...
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