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Article

FRZB1 rs2242070 polymorphisms is associated with brick tea type skeletal fluorosis in Kazakhs, but not in Tibetans, China.

Archives of toxicology - 1 Jul 2018

Yang Yanmei, Zhao Qiaoshi, Liu Yang, Liu Xiaona, Chu Yanru, Yan Huazhu, Fan Yumei, Huo Simeng, Wang Limei, Lou Qun, Guo Ning, Sun Dianjun, Gao Yanhui

Abstract excerpt

Skeletal fluorosis is a metabolic bone and joint disease caused by excessive accumulation of fluoride in the bones. Compared with Kazakhs, Tibetans are more likely to develop moderate and severe brick tea type skeletal fluorosis, although they have similar fluoride exposure. Single nucleotide polymorphisms (SNPs) in frizzled-related protein (FRZB) have been associated with osteoarthritis, but their association...

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Source

Identifiers

PMID: 29785637
DOI: 10.1007/s00204-018-2217-9

Genes

FRZB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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