Article
Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.
Arthritis and rheumatism - 1 May 2005
Alizadeh B Z, Njajou O T, Bijkerk C, Meulenbelt I, Wildt S C De, Hofman A, Pols H A P, Slagboom P E, Duijn C M Van
Abstract excerpt
OBJECTIVE: Type IX collagen proteoglycan is an important protein in collagen networks and has been implicated in hip osteoarthritis (OA). We studied 2 COL9A1 markers (509-8B2 and 509-12B1) in relation to radiographic OA, within the framework of the Rotterdam Study, a population-based study of 7,983 subjects ages 55 years and older. METHODS: We used 2 different designs, as follows: 1) a linkage study of 83...
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