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Article

The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk.

Carcinogenesis - 1 Sept 2007

Shanmugam Kalai S, Brenner Hermann, Hoffmeister Michael, Chang-Claude Jenny, Burwinkel Barbara

Abstract excerpt

The Wnt-beta-catenin pathway plays a central role in colorectal tumorigenesis. Frizzled-related protein (FRZB, also termed secreted frizzled-related protein 3, sFRP3) antagonizes the signaling of wingless (Wnt) ligands through the frizzled membrane-bound receptors, resulting in beta-catenin desta...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17420170
DOI: 10.1093/carcin/bgm077

Genes

FRZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17420170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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