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Article

Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Dec 2007

Gordon Andrew, Southam Lorraine, Loughlin John, Wilson Anthony Gerard, Stockley Ian, Hamer Andrew J, Eastell Richard, Wilkinson Jeremy Mark

Abstract excerpt

Secreted frizzled-related protein-3 (sFRP3) antagonizes ligands that promote new bone formation in adult tissues. We examined whether variation in the FRZB gene that encodes sFRP3 is associated with development of osteolysis or heterotopic ossification (HO) after total hip arthroplasty (THA). Genomic DNA was extracted from 609 subjects (osteolysis group n = 268) at a mean of 11 years following cemented THA for...

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Source

Identifiers

PMID: 17600823
DOI: 10.1002/jor.20446

Genes

FRZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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