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Article

Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis.

Human molecular genetics - 1 May 2006

Edenberg Howard J, Xuei Xiaoling, Chen Hui-Ju, Tian Huijun, Wetherill Leah Flury, Dick Danielle M, Almasy Laura, Bierut Laura, Bucholz Kathleen K, Goate Alison, Hesselbrock Victor, Kuperman Samuel, Nurnberger John, Porjesz Bernice, Rice John, Schuckit Marc, Tischfield Jay, Begleiter Henri, Foroud Tatiana

Abstract excerpt

Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test. There was strong evidence that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16571603
DOI: 10.1093/hmg/ddl073

Genes

ADH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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