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Article

Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.

Alcoholism, clinical and experimental research - 1 May 2008

Kuo Po-Hsiu, Kalsi Gursharan, Prescott Carol A, Hodgkinson Colin A, Goldman David, van den Oord Edwin J, Alexander Jeffry, Jiang Cizhong, Sullivan Patrick F, Patterson Diana G, Walsh Dermot, Kendler Kenneth S, Riley Brien P

Abstract excerpt

BACKGROUND: The genes coding for ethanol metabolism enzymes [alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)] have been widely studied for their influence on the risk to develop alcohol dependence (AD). However, the relation between polymorphisms of these metabolism genes and AD in Caucasian subjects has not been clearly established. The present study examined evidence for the association of alcohol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18331377
DOI: 10.1111/j.1530-0277.2008.00642.x
PMCID: PMC2665790

Genes

ALDH2
ADH4
ADH5
ADH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.PMID 18331377Read ↗

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Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Semantic proximity Read ↗

Rare ADH variant constellations are specific for alcohol dependence.Semantic proximity Read ↗

ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.Semantic proximity Read ↗

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A Genome-Wide Association Study Reveals New Genes in a Molecular Network Associated With Alcohol Dependence and Related Clinical MeasuresSemantic proximity Read ↗

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