Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.

doi:10.1111/j.1369-1600.2011.00395.x

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Article

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.

Addiction biology - 1 Jan 2012

Frank Josef, Cichon Sven, Treutlein Jens, Ridinger Monika, Mattheisen Manuel, Hoffmann Per, Herms Stefan, Wodarz Norbert, Soyka Michael, Zill Peter, Maier Wolfgang, Mössner Rainald, Gaebel Wolfgang, Dahmen Norbert, Scherbaum Norbert, Schmäl Christine, Steffens Michael, Lucae Susanne, Ising Marcus, Müller-Myhsok Bertram, Nöthen Markus M, Mann Karl, Kiefer Falk, Rietschel Marcella

Abstract excerpt

Alcohol dependence (AD) is an important contributory factor to the global burden of disease. The etiology of AD involves both environmental and genetic factors, and the disorder has a heritability of around 50%. The aim of the present study was to identify susceptibility genes for AD by performing a genome-wide association study (GWAS). The sample comprised 1333 male in-patients with severe AD according to the...

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PMID: 22004471
DOI: 10.1111/j.1369-1600.2011.00395.x
PMCID: PMC3245349

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