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Article

Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.

Alcoholism, clinical and experimental research - 1 Feb 2011

Liu Jixia, Zhou Zhifeng, Hodgkinson Colin A, Yuan Qiaoping, Shen Pei-Hong, Mulligan Connie J, Wang Alex, Gray Rebecca R, Roy Alec, Virkkunen Matti, Goldman David, Enoch Mary-Anne

Abstract excerpt

BACKGROUND: Ethanol is metabolized by 2 rate-limiting reactions: alcohol dehydrogenases (ADH) convert ethanol to acetaldehyde that is subsequently metabolized to acetate by aldehyde dehydrogenases (ALDH). Approximately 50% of East Asians have genetic variants that significantly impair this pathway and influence alcohol dependence (AD) vulnerability. We investigated whether variation in alcohol metabolism genes...

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Source

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Identifiers

PMID: 21083667
DOI: 10.1111/j.1530-0277.2010.01346.x
PMCID: PMC3026908

Genes

ADH4
ADH5
ADH6
ADH7
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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