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Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways.

DNA repair - 10 May 2006

Zheng Huyong, Wang Xin, Legerski Randy J, Glazer Peter M, Li Lei

Abstract excerpt

DNA interstrand cross-links (ICLs) are complex DNA lesions generated by bifunctional alkylating agents, a class of compounds extensively used in cancer chemotherapy. Formation of an ICL covalently links the opposing strands of the double helix and results in severe disruptions of normal DNA functions, such as replication, transcription, and recombination. Because of the structural complexity, ICLs are most likely...

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PMID: 16569514
DOI: 10.1016/j.dnarep.2006.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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