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Article

Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links.

Molecular and cellular biology - 1 Jan 2003

Zheng Huyong, Wang Xin, Warren Amy J, Legerski Randy J, Nairn Rodney S, Hamilton Joshua W, Li Lei

Abstract excerpt

Interstrand cross-links (ICLs) make up a unique class of DNA lesions in which both strands of the double helix are covalently joined, precluding strand opening during replication and transcription. The repair of DNA ICLs has become a focus of study since ICLs are recognized as the main cytotoxic lesion inflicted by an array of alkylating compounds used in cancer treatment. As is the case for double-strand breaks,...

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Identifiers

PMID: 12509472
DOI: 10.1128/MCB.23.2.754-761.2003
PMCID: PMC151552

Genes

POLH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links.PMID 12509472Read ↗

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