Article
Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links.
Molecular and cellular biology - 1 Jan 2003
Zheng Huyong, Wang Xin, Warren Amy J, Legerski Randy J, Nairn Rodney S, Hamilton Joshua W, Li Lei
Abstract excerpt
Interstrand cross-links (ICLs) make up a unique class of DNA lesions in which both strands of the double helix are covalently joined, precluding strand opening during replication and transcription. The repair of DNA ICLs has become a focus of study since ICLs are recognized as the main cytotoxic lesion inflicted by an array of alkylating compounds used in cancer treatment. As is the case for double-strand breaks,...
Topics
- Animals
- Antibodies, Monoclonal
- Base Sequence
- CHO Cells
- Cell Line
- Cricetinae
- Cross-Linking Reagents
- DNA Damage
- DNA Repair
- DNA, Complementary
- DNA-Directed DNA Polymerase
- Humans
- Immunoblotting
- Luciferases