The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro.

doi:10.1038/nsmb1120

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Article

The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro.

Nature structural & molecular biology - 1 Aug 2006

Cipak Lubos, Watanabe Norifumi, Bessho Tadayoshi

Abstract excerpt

Using a defined substrate DNA with a single psoralen interstrand cross-link (ICL), we studied the molecular mechanism of human ICL repair. In vitro ICL repair by human extracts is dependent on replication and is a largely error-free process. Extracts from a human BRCA2-defective mutant cell line, CAPAN-1, are severely compromised in ICL repair. Specifically, 'unhooked' but not fully repaired products accumulate...

Topics

BRCA2 Protein
Cross-Linking Reagents
DNA Repair
DNA Replication
Ficusin
Humans
Mutation
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 16845393
DOI: 10.1038/nsmb1120

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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