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Article

The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro.

Nature structural & molecular biology - 1 Aug 2006

Cipak Lubos, Watanabe Norifumi, Bessho Tadayoshi

Abstract excerpt

Using a defined substrate DNA with a single psoralen interstrand cross-link (ICL), we studied the molecular mechanism of human ICL repair. In vitro ICL repair by human extracts is dependent on replication and is a largely error-free process. Extracts from a human BRCA2-defective mutant cell line, CAPAN-1, are severely compromised in ICL repair. Specifically, 'unhooked' but not fully repaired products accumulate...

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Identifiers

PMID: 16845393
DOI: 10.1038/nsmb1120

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro.PMID 16845393Read ↗

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link RepairSemantic proximity Read ↗

Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells.Semantic proximity Read ↗

Initiation of DNA interstrand cross‐link repair in mammalian cellsSemantic proximity Read ↗

Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand.Semantic proximity Read ↗

HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells.Semantic proximity Read ↗

DNA repair fidelity of base excision repair pathways in human cell extracts.Semantic proximity Read ↗

Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cellsSemantic proximity Read ↗

Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways.Semantic proximity Read ↗

Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair.Semantic proximity Read ↗

Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells.Semantic proximity Read ↗

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinksSemantic proximity Read ↗

Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations.Semantic proximity Read ↗

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