Article
The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.
Nucleic acids research - 1 Nov 2012
Mendez-Bermudez Aaron, Hidalgo-Bravo Alberto, Cotton Victoria E, Gravani Athanasia, Jeyapalan Jennie N, Royle Nicola J
Abstract excerpt
Approximately 10% of all cancers, but a higher proportion of sarcomas, use the recombination-based alternative lengthening of telomeres (ALT) to maintain telomeres. Two RecQ helicase genes, BLM and WRN, play important roles in homologous recombination repair and they have been implicated in telomeric recombination activity, but their precise roles in ALT are unclear. Using analysis of sequence variation present...
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