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Article

Initiation of DNA interstrand cross‐link repair in mammalian cells

26 Mar 2010

Abstract excerpt

Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents are well established in clinical use, and numerous repair proteins have been implicated in the initial events of mammalian ICL repair, the precise mechanistic details of these...

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PMID: 20658650
DOI: 10.1002/em.20559

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