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Article

HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells.

Nucleic acids research - 18 Feb 2016

Mukherjee Anirban, Vasquez Karen M

Abstract excerpt

Many effective agents used in cancer chemotherapy cause DNA interstrand crosslinks (ICLs), which covalently link both strands of the double helix together resulting in cytotoxicity. ICLs are thought to be processed by proteins from a variety of DNA repair pathways; however, a clear understanding of ICL recognition and repair processing in human cells is lacking. Previously, we found that the high mobility group...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoresis, Agar Gel

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Share to Xeroderma Pigmentosum Group A Protein

Source

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Identifiers

PMID: 26578599
DOI: 10.1093/nar/gkv1183
PMCID: PMC4756816

Genes

HMGB1
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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