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Article

Identification of the key residues responsible for the assembly of selenodeiodinases.

The Journal of biological chemistry - 26 May 2006

Simpson Gregory I C, Leonard Deborah M, Leonard Jack L

Abstract excerpt

Type I deiodinase is the best characterized member of a small family of selenoenzymes catalyzing the bioactivation and disposal of thyroid hormone. This enzyme is an integral membrane protein composed of two 27-kDa subunits that assemble into a functional enzyme after translation using a highly conserved sequence of 16 amino acids in the C-terminal half of the polypeptide, (148)DFLXXYIXEAHXXDGW(163). In this...

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PMID: 16565517
DOI: 10.1074/jbc.M600783200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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