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Article

Mutational effects on inclusion body formation in the periplasmic expression of the immunoglobulin VL domain REI.

Folding & design - 1 Jan 1996

Chan W, Helms L R, Brooks I, Lee G, Ngola S, McNulty D, Maleeff B, Hensley P, Wetzel R

Abstract excerpt

BACKGROUND: Inclusion body (IB) formation in bacteria is an important example of protein misassembly, a phenomenon which also includes folding-dependent aggregation in vitro and amyloid deposition in human disease. Previous studies of mutational effects in other systems implicate the stability of a folding intermediate-rather than the native state-as playing a key role in IB formation. To contribute to an...

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PMID: 9079368
DOI: 10.1016/s1359-0278(96)00017-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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