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Article

Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.

The Journal of biological chemistry - 20 Oct 2006

Zeöld Anikó, Pormüller Lívia, Dentice Monica, Harney John W, Curcio-Morelli Cyntia, Tente Susana M, Bianco Antonio C, Gereben Balázs

Abstract excerpt

Thyroid hormone activation is catalyzed by two deiodinases, D1 and D2. Whereas D1 is a stable plasma membrane protein, D2 is resident in the endoplasmic reticulum (ER) and has a 20-min half-life due to selective ubiquitination and proteasomal degradation. Here we have shown that stable retention...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Iodide Peroxidase

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Source

Identifiers

PMID: 16928685
DOI: 10.1074/jbc.M604728200

Genes

SEC62

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16928685-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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