Article
Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates.
Structure (London, England : 1993) - 6 Sept 2016
Assar Zahra, Nossoni Zahra, Wang Wenjing, Santos Elizabeth M, Kramer Kevin, McCornack Colin, Vasileiou Chrysoula, Borhan Babak, Geiger James H
Abstract excerpt
Human Cellular Retinol Binding Protein II (hCRBPII), a member of the intracellular lipid-binding protein family, is a monomeric protein responsible for the intracellular transport of retinol and retinal. Herein we report that hCRBPII forms an extensive domain-swapped dimer during bacterial expression. The domain-swapped region encompasses almost half of the protein. The dimer represents a novel structural...
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