Article
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Science (New York, N.Y.) - 15 Mar 1991
Kinzler K W, Nilbert M C, Vogelstein B, Bryan T M, Levy D B, Smith K J, Preisinger A C, Hamilton S R, Hedge P, Markham A
Abstract excerpt
Recent studies have suggested the existence of a tumor suppressor gene located at chromosome region 5q21. DNA probes from this region were used to study a panel of sporadic colorectal carcinomas. One of these probes, cosmid 5.71, detected a somatically rearranged restriction fragment in the DNA from a single tumor. Further analysis of the 5.71 cosmid revealed two regions that were highly conserved in rodent DNA....
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