Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

doi:10.1126/science.1848370

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Article

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

Science (New York, N.Y.) - 15 Mar 1991

Kinzler K W, Nilbert M C, Vogelstein B, Bryan T M, Levy D B, Smith K J, Preisinger A C, Hamilton S R, Hedge P, Markham A

Abstract excerpt

Recent studies have suggested the existence of a tumor suppressor gene located at chromosome region 5q21. DNA probes from this region were used to study a panel of sporadic colorectal carcinomas. One of these probes, cosmid 5.71, detected a somatically rearranged restriction fragment in the DNA f...

Topics

Adenomatous Polyposis Coli
Amino Acid Sequence
Animals
Base Sequence
Chromosomes, Human, Pair 5
Colorectal Neoplasms
Exons
GTP-Binding Proteins
Gene Expression
Genes, Tumor Suppressor
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligonucleotides

Polymerase Chain Reaction

Proteins

Rats

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 1848370
DOI: 10.1126/science.1848370

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1848370-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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