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Article

Identification of FAP Locus Genes from Chromosome 5q21

9 Aug 1991

Abstract excerpt

Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers, particularly those associated with familial adenomatous polyposis (FAP). To facilitate the identification of genes from this locus, a portion of the region that is tightly linked to FAP was cloned. Six contiguous stretches of sequence (contigs) containing approximately 5.5 Mb of DNA were...

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PMID: 1651562
DOI: 10.1126/science.1651562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of FAP Locus Genes from Chromosome 5q21PMID 1651562Read ↗

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.Semantic proximity Read ↗

Genetic characterization of the APC locus involved in familial adenomatous polyposis.Semantic proximity Read ↗

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.Semantic proximity Read ↗

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.Semantic proximity Read ↗

Cell and molecular biology of gastrointestinal tract cancer.Semantic proximity Read ↗

Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.Semantic proximity Read ↗

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.Semantic proximity Read ↗

Localization of the gene for familial adenomatous polyposis on chromosome 5.Semantic proximity Read ↗

Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis.Semantic proximity Read ↗

Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.Semantic proximity Read ↗

Suppressor gene alterations in the colorectal adenoma-carcinoma sequence.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

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