Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.

doi:10.1084/jem.181.4.1587

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Article

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.

The Journal of experimental medicine - 1 Apr 1995

Padovan E, Giachino C, Cella M, Valitutti S, Acuto O, Lanzavecchia A

Abstract excerpt

We have examined the extent of allelic exclusion at the T cell receptor (TCR) beta locus using monoclonal antibodies specific for V beta products. A small proportion (approximately 1%) of human peripheral blood T cells express two V beta as determined by flow cytometric analysis, isolation of rep...

Topics

Alleles
Amino Acid Sequence
Antibodies, Monoclonal
Base Sequence
Cell Separation
Diploidy
Flow Cytometry
Gene Expression Regulation
Humans
Immunophenotyping
Leukocyte Common Antigens
Molecular Sequence Data
Polymerase Chain Reaction
Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 7699339
DOI: 10.1084/jem.181.4.1587
PMCID: PMC2191970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7699339-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Signal Transduction

T-Lymphocyte Subsets