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Article

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.

The Journal of experimental medicine - 1 Apr 1995

Padovan E, Giachino C, Cella M, Valitutti S, Acuto O, Lanzavecchia A

Abstract excerpt

We have examined the extent of allelic exclusion at the T cell receptor (TCR) beta locus using monoclonal antibodies specific for V beta products. A small proportion (approximately 1%) of human peripheral blood T cells express two V beta as determined by flow cytometric analysis, isolation of representative clones, and sequencing of the corresponding V beta chains. Dual beta T cells are present in both the...

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Identifiers

PMID: 7699339
DOI: 10.1084/jem.181.4.1587
PMCID: PMC2191970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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