Article
Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1995
Balomenos D, Balderas R S, Mulvany K P, Kaye J, Kono D H, Theofilopoulos A N
Abstract excerpt
Recent studies have documented incomplete TCR V alpha-chain allelic exclusion and dual V alpha-bearing T cells. Herein, we show that V beta allelic exclusion is also incomplete, since a significant proportion of peripheral T cells express dual V beta in both TCR transgenic and normal mice. Studies in TCR transgenic mice indicated that although a small proportion of T cells escaped allelic exclusion in the thymus,...
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