Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.

doi:10.1073/pnas.121179998

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Article

Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2001

Sant'Angelo D B, Cresswell P, Janeway C A, Denzin L K

Abstract excerpt

T cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein. Genetic allelic exclusion has been shown to be leaky for the beta chain and, more commonly, for the alpha chain. Here, we demonstrate an additional mechanism by which T cells can maintain monoclonality. T cells from double TCR...

Topics

Alleles
Dimerization
Flow Cytometry
Humans
RNA, Messenger
Receptors, Antigen, T-Cell, alpha-beta
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes
Transgenes

Source

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Identifiers

PMID: 11381132
DOI: 10.1073/pnas.121179998
PMCID: PMC34437

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