Article
A voltage sensor-domain protein is a voltage-gated proton channel.
Science (New York, N.Y.) - 28 Apr 2006
Sasaki Mari, Takagi Masahiro, Okamura Yasushi
Abstract excerpt
Voltage-gated proton channels have been widely observed but have not been identified at a molecular level. Here we report that a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel. Cells overexpressing this protein showed depolarization-induced outward currents accompanied by tail currents. Current reversal occured at equilibrium...
Topics
- Animals
- Cell Line
- Ciona intestinalis
- Electric Conductivity
- Humans
- Hydrogen-Ion Concentration
- Ion Channel Gating
- Ion Channels
- Membrane Potentials
- Mice
- Molecular Sequence Data
- Mutation
- Patch-Clamp Techniques
- Protein Structure, Tertiary
- Protons
- Transfection