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Article

A voltage sensor-domain protein is a voltage-gated proton channel.

Science (New York, N.Y.) - 28 Apr 2006

Sasaki Mari, Takagi Masahiro, Okamura Yasushi

Abstract excerpt

Voltage-gated proton channels have been widely observed but have not been identified at a molecular level. Here we report that a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel. Cells overexpressing this protein showed depolarization-induced outward currents accompanied by tail currents. Current reversal occured at equilibrium...

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Identifiers

PMID: 16556803
DOI: 10.1126/science.1122352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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