Article
Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2011
Shaya David, Kreir Mohamed, Robbins Rebecca A, Wong Stephanie, Hammon Justus, Brüggemann Andrea, Minor Daniel L
Abstract excerpt
Many voltage-gated ion channel (VGIC) superfamily members contain six-transmembrane segments in which the first four form a voltage-sensing domain (VSD) and the last two form the pore domain (PD). Studies of potassium channels from the VGIC superfamily together with identification of voltage-sensor only proteins have suggested that the VSD and the PD can fold independently. Whether such transmembrane modularity...
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