Article
Contribution of HLA class I allele expression to CD8+ T-cell responses against Epstein-Barr virus.
Scandinavian journal of immunology - 1 Feb 2002
Höllsberg P
Abstract excerpt
Most immune responses to viral infections involve CD8+ T cells recognizing viral peptides of typically 9-10 amino acids in the groove of major histocompatibility complex (MHC) class I. Importantly, CD8+ T-cell responses appear to focus on few viral epitopes, a phenomenon termed immunodominance. While the understanding of this phenomenon has been based largely on experimental mice models, it is imperative to...
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