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Article

Absence of<i>Chx10</i>Causes Neural Progenitors to Persist in the Adult Retina

29 Dec 2005

Abstract excerpt

PURPOSE: Mutation of the Chx10 homeobox gene in mice and humans causes congenital blindness and microphthalmia (small eyes). This study used Chx10-/- (ocular retardation) mice to investigate how lack of Chx10 affects progenitor/stem cell behavior in the retina and ciliary epithelium (CE). METHODS: The distribution of mitotic retinal progenitor cells (RPCs) during embryonic development was analyzed using...

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Identifiers

PMID: 16384989
DOI: 10.1167/iovs.05-0428

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Related research

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Absence of<i>Chx10</i>Causes Neural Progenitors to Persist in the Adult RetinaPMID 16384989Read ↗

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Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.Semantic proximity Read ↗

Ciliary marginal zone of the developing human retina maintains retinal progenitor cells until late gestational stagesSemantic proximity Read ↗

Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina.Semantic proximity Read ↗

Microphthalmia and disrupted retinal development due to a <i>LacZ</i> knock-in/knock-out allele at the <i>Vsx2</i> locusSemantic proximity Read ↗

Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.Semantic proximity Read ↗

The neuronal fate determinants SOX4/11 control mitotic fidelity of adult hippocampal precursor cellsSemantic proximity Read ↗

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